So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tsotinis, Andrew; Afroudakis, Pandelis A.; Davidson, Kathryn; Prashar, Anjali; Sugden, David researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.They published the article 《Design, Synthesis, and Melatoninergic Activity of New Azido- and Isothiocyanato-Substituted Indoles》 about this compound( cas:21778-81-4 ) in Journal of Medicinal Chemistry. Keywords: indole azido isothiocyanato preparation melatoninergic. We’ll tell you more about this compound (cas:21778-81-4).
To develop irreversibly binding ligands for the melatonin receptor(s) as tools for tracing the primary melatonin binding site, novel melatoninergic azido- and isothiocyanato-substituted indoles were designed and synthesized. All active compounds were partial agonists or antagonists in the Xenopus melanophore assay, the most potent being 3-(2-azidoethyl)-5-methoxyindole and 3-(2-isothiocyanatoethyl)-5-methoxyindole.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem