With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108784-42-5,6-Fluoropyridazin-3-amine,as a common compound, the synthetic route is as follows.
6-Fluoropyridazin-3-ylamine (10 g, 89 mmol) was combined with a 50% (w/v) aqueous solution of chloroacetaldehyde (23 mL, 177 mmol) in n-butanol (150 mL) and stirred at reflux for 1h. The cooled reaction solution was reduced in volume and diluted with diethyl ether to precipitate a brown solid, which was collected by filtration, to yield 12.0 g of the titled compound. LRMS (ESI) m/z 138.0[(M+H)]+,calc?d for C6H4FN3: 137.12., 108784-42-5
108784-42-5 6-Fluoropyridazin-3-amine 13719068, apyridazine compound, is more and more widely used in various fields.
Reference：
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Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem