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A new heterocyclic reductive alkylating agent, 6-chloro-2-chloromethyl-3-nitroimidazo[1,2-b]pyridazine, was synthesized for the first time. It was shown to react under phase-transfer catalysis conditions with 2-nitropropane anion by an SRN1 mechanism to give excellent yield of isopropylidene derivative formed from a base-promoted nitrous acid elimination of C-alkylation product. Extension of this SRN1 reaction to various nitronate anions led to a new class of 3-nitroimidazo[1,2-b]pyridazine derivatives bearing a trisubstituted double bond at the 2-position.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 141-30-0SDS of cas: 141-30-0, you can also check out more blogs aboutSDS of cas: 141-30-0
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1923 – PubChem