Computed Properties of C4H2Cl2N2, The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research.
The heterodimeric transmembrane alphav integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyrate-based antagonists of the vitronectin receptors alphavbeta3 and alphavbeta5 significantly change the biological activities against alphavbeta6 and alphavbeta8. This resulted in the discovery of a pan alphav antagonist (compound 39, 4-40 nM for the integrin receptors named above) possessing excellent oral pharmacokinetic properties in rats (with a clearance of 7.6 mL/(min kg) and a bioavailability of 97%).
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Pyridazine – Wikipedia,
Pyridazine | C4H4N1598 – PubChem