Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Synthetic Route of 141-30-0. Introducing a new discovery about 141-30-0, Name is 3,6-Dichloropyridazine
An efficient synthesis of a series of 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines is described via intramolecular oxidative cyclization of various 6-chloropyridazin-3-yl hydrazones with iodobenzene diacetate. The structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, NMR (1H and 13C) and mass spectral data. All the thirty three compounds 3a-q and 4b-q synthesized in the present study were evaluated for their in vitro cytotoxic activities against two Acute Lymphoblastic Leukemia (ALL) cell lines named, SB-ALL and NALM-6, and a human breast adenocarcinoma cell lines (MCF-7). The results revealed that triazoles 4 exhibit better cytotoxicity than their hydrazone precursors 3. Among triazoles, compounds 4f, 4j and 4q exhibited potent cytotoxic activity against SB-ALL and NALM-6 with IC50 values in the range of ?1.64?5.66 muM and ?1.14?3.7 muM, respectively, compared with doxorubicin (IC50 = 0.167 muM, SB-ALL). Compounds 4f, 4j and 4q were subjected to apoptosis assay after 48 h treatment and these compounds induced apoptosis of NALM-6 cells via caspase 3/7 activation. Results revealed that compound 4q represents potential promising lead.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research. 141-30-0 is helpful to your research. Synthetic Route of 141-30-0
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1806 – PubChem