In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Synthetic Route of 5788-58-9, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5788-58-9, name is 4,5-Dibromopyridazin-3(2H)-one. In an article，Which mentioned a new discovery about 5788-58-9
High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3) Such inhibitors are of interest due to PFKFB3’s control of the important glycolytic pathway used by cancer cells to generate ATP A series of analogues was synthesized to study structure-activity relationships key to enzyme inhibition Changes to the triazolo or pyridazinone rings were not favoured, but limited-size substitutions on the aryl ring provided modest increases in potency against the enzyme Selected analogues and literature-described inhibitors were evaluated for their ability to suppress the glycolytic pathway, as detected by a decrease in lactate production, but none of these compounds demonstrated such suppression at non-cytotoxic concentrations
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 5788-58-9Synthetic Route of 5788-58-9
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3168 – PubChem