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A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of triethylamine as a base, is described. The methodology is general and efficient despite noticeable difference in reactivity between diazines. While dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research. 141-30-0 is helpful to your research. Related Products of 141-30-0
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1894 – PubChem