Month: August 2021

1837-55-4, Name is 3,5-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 3,5-DichloropyridazineIn an article, once mentioned the new application about 1837-55-4.

The present invention relates to a compound of formula I, HetAr is a five or six membered heteroaryl group, selected from wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen, and may be the same or different, if two R1 occur; R2 is lower alkyl or a mono- or polydeutered derivative thereof, lower alkyl substituted by halogen or lower alkoxy, lower alkenyl unsubstituted or substituted by halogen, cycloalkyl or CH2-cycloalkyl unsubstituted or substituted by halogen, heterocycloalkyl or CH2-heterocycloalkyl unsubstituted or substituted by lower alkyl; R3 is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy substituted by halogen or S(0)2-lower alkyl; n is 1, 2 or 3; if n is >1, then R3 may be the same or different; or to a pharmaceutically active acid addition salt thereof, to a racemic mixture or to its corresponding enantiomer and/or an optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Alzheimer’s disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1139 – PubChem

Reference of 141-30-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 141-30-0, molcular formula is C4H2Cl2N2, introducing its new discovery.

We have recently shown that an aryloaminopyridazine derivarive of GABA, SR 95103 <2-(3-carboxypropyl)-3-amino-4-methyl-6-phenylpyridazinium chloride>, is a selective and competitive GABA-A receptor antagonist.In order to further explore the structural requirements for GABA receptor affinity, we synthesized a series of 38 compounds by attaching various pyridazinic structures to GABA or GABA-like side chains.Most of the compounds displaced <3H>GABA from rat brain membranes.All the active compounds antagonized the GABA-elicited enhancement of <3H>diazepam binding, strongly suggesting that all these compounds are GABA-A receptor antagonists.None of the compounds that displaced <3H>GABA from rat brain membranes interacted with other GABA recognition sites (GABA-B receptor, GABA uptake binding site, glutamate decarboxylase, GABA-transaminase).They did not interact with the Cl- ionophore associated with the GABA-A receptor and did not interact with the benzodiazepine, strychnine, and glutamate binding sites.Thus these compounds appear to be specific GABA-A receptor antagonists.In terms of structure-activity, it can be concluded that a GABA moiety bearing a positive charge is necessary for optimal GABA-A receptor recognition.Additional binding sites are tolerated only if they are part of a charge-delocalized amidinic or guanidinic system.If this delocalization is achieved by linking a butyric acid moiety to the N(2) nitrogen of a 3-aminopyridazine, GABA-antagonistic character is produced.The highest potency (ca.250 times bicuculline) was observed when an aromatic ? system, bearing electron-donating substituents, was present on the 6-position of the pyridazine ring.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 141-30-0 is helpful to your research. Application of 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1955 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 1121-79-5, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1121-79-5

A crystalline form of 6-{2-[l-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}- 3-ethoxy-l,2-benzoxazole is provided which is useful in the treatment of infections caused by Picornaviridae such as human rhinovirus (HRV), and in particular the crystal form is an anhydrous crystalline free base form of 6-{2-[l-(6-methyl-3- pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-l,2-benzoxazole. In addition, a method of manufacturing the free base crystalline form is also provided, including a step of micronizing the compound particles, optionally using a wetting agent, as well as pharmaceutical compositions incorporating the free base crystalline form such as tablets or suspensions, and methods of therapeutic treatments using this form and pharmaceutical compositions thereof.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N593 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 3,6-Dichloropyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

(Equation presented) The catalytic asymmetric dihydroxylation of olefins has been accomplished with high enantioselectivities using a proline-based catalyst. The pre-transition-state assembly for styrene is shown.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. category: pyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 141-30-0, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1738 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: pyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 27372-38-9, Name is 6-Oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid, molecular formula is C5H6N2O3

Herein, we described the design and synthesis of a series of pyridazine-3-carboxamides to be CB2-selective agonists via a combination of scaffold hopping and bioisosterism strategies. The compounds were subjected to assessment of their potential activities through calcium mobilization assays. Among the tested derivatives, more than half of these compounds exhibited moderate to potent CB2 agonist activity. Six compounds showed EC50 values below 35 nM, and several derivatives also exhibited significantly enhanced potency and high selectivity at the CB2 receptor over the CB1 receptor. Specifically, compound 26 showed the highest CB2 agonist activity (EC50 = 3.665 ± 0.553 nM) and remarkable selectivity (Selectivity Index > 2729) against CB1. In addition, logPs of some representative compounds were measured to display significantly decreased values in comparison with GW842166X. Furthermore, docking simulations were conducted to explain the interaction mode of this series.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C5H6N2O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 27372-38-9, in my other articles.

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1019 – PubChem

89180-50-7, Name is 5,6-Dichloropyridazin-4-amine, belongs to pyridazine compound, is a common compound. COA of Formula: C4H3Cl2N3In an article, once mentioned the new application about 89180-50-7.

New syntheses of oxazolo<4,5-d>pyridazine derivatives 7 and 11 were achieved by the cyclization of substituted N-pyridazin-5-ylformamide oximes 6 and 10.Under mild reaction conditions the transformations of the substituted amino group at position 2 of the oxazolo<4,5-d>pyridazine system 7 occured to produce the compounds 11, 14, and 15, while under more drastic reaction conditions the nucleophilic attack at carbon at position 2 followed by the ring opening of the oxazole part of the molecule was observed to give the compounds 13, 16, 17 and 18. – Keywords: Cyclization with C-O bond formation; Substituted N-pyridazin-5-ylformamidines and -formamide oximes; Oxazolo<4,5-d>pyridazines; Ring opening of oxazolo<4,5-d>pyridazines

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2215 – PubChem

Reference of 1114563-58-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1114563-58-4, Name is 6-Chloro-2,4-dimethylpyridazin-3(2H)-one, molecular formula is C6H7ClN2O. In a Patent，once mentioned of 1114563-58-4

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1114563-58-4. In my other articles, you can also check out more blogs about 1114563-58-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2081 – PubChem

Reference of 18591-82-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 18591-82-7, molcular formula is C5H7N3, introducing its new discovery.

The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for? the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 18591-82-7 is helpful to your research. Electric Literature of 18591-82-7

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N207 – PubChem

Reference of 141-30-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article，once mentioned of 141-30-0

Chloropyridazine derivatives 1, 3, 5, 7 and 10a-c were reacted with N,N-dimethylformamide under reflux condition to give the corresponding N,N-dimethylaminopyridazines 2, 4, 6, 8, 9 and 11a-c regioselectively.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 141-30-0

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1961 – PubChem

Electric Literature of 286946-24-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 286946-24-5, Name is Methyl 3,6-dichloropyridazine-4-carboxylate, molecular formula is C6H4Cl2N2O2. In a Patent，once mentioned of 286946-24-5

The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 286946-24-5. In my other articles, you can also check out more blogs about 286946-24-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2892 – PubChem