Month: August 2021

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C5H4N2O2. Introducing a new discovery about 2164-61-6, Name is Pyridazine-3-carboxylic acid

Design, syntheses and structure-activity relationships of N-acetylated piperazine privileged structures containing MC4R agonist compounds were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N483 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: pyridazine. Introducing a new discovery about 20375-65-9, Name is 3-Phenyl-6-chloropyridazine

A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation of Pro- or Hyp-derived 2,5-diketopiperazines (2,5-DKPs) and bis-DKPs with a disulfide linker. This method can be used for the construction of 2,5-DKP compound libraries and for the synthesis of natural products with diketopiperazine cores. This journal is

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2714 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C10H7ClN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20375-65-9, name is 3-Phenyl-6-chloropyridazine. In an article，Which mentioned a new discovery about 20375-65-9

The present invention provides a novel compound having a superior activity as an ERR-alpha modulator and useful as an agent for the prophylaxis or treatment of ERR-alpha associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2570 – PubChem

Synthetic Route of 64068-00-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 64068-00-4, 6-Chloro-4-methylpyridazin-3-amine, introducing its new discovery.

This invention, relates to imidazopyridazine substituted piperidine derivatives (I) and their use as orexin antagonists

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 64068-00-4. In my other articles, you can also check out more blogs about 64068-00-4

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1034 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Application In Synthesis of Ethyl 4,6-dichloropyridazine-3-carboxylate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 679406-03-2, Name is Ethyl 4,6-dichloropyridazine-3-carboxylate, molecular formula is C7H6Cl2N2O2

Disclosed is crystalline Form B of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl) amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form B is the HCl salt of a neat crystalline form. Characterization data for Form B are disclosed.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2968 – PubChem

Application of 17321-38-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17321-38-9, Name is 3-Iodo-6-isopropoxypyridazine, molecular formula is C7H9IN2O. In a Patent，once mentioned of 17321-38-9

invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3220 – PubChem

Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 141-30-0

The present invention relates to novel heteroaryl diazabicycloalkane derivatives represented by general formula (I), any of its enantiomers or any mixture thereof, an N oxide thereof, a pharmaceutically acceptable salt thereof, in a labelled or un-labelled form, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1277 – PubChem

Reference of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 141-30-0

This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1486 – PubChem

Related Products of 141-30-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 141-30-0, Name is 3,6-Dichloropyridazine,introducing its new discovery.

Background: Brain cancer (neuroblastoma) and liver cancer (hepatocellular carcinoma) are common cancer types among others worldwide which do not have a radical treatment and cure. Objective: In the current study, five novel pyridazinone derivates bearing benzelhydrazone moiety at second position were synthesized and evaluated for their cytotoxic activity against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. The aim of the current study is to identify antiproliferative activity of five novel pyridazinone derivates against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. Method: The compounds were synthesized by the reacting 6-[4-(phenyl/4-chlorophenyl)piperazine-1-yl]-3(2H)-pyridazinone-2-yl acetohydrazide with benzaldehyde in ethanol. The in vitro antiproliferative activities were determined with MTT assay. Bax, Bcl-2 and Casp3 gene expression levels were detected with RT-PCR analyses. Results: The lowest IC50 was observed for compound 4 in SHSY5Y and HEP3B cells. Apoptosis increased in cancer cells which was shown by changes inBax, Bcl-2 and Casp3 gene expression levels with 1-5 compound therapy. Conclusion: Novel pyridazinone derivates might be promising agents as new chemotherapeutic candidates in brain and liver cancer.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1651 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 141-30-0, name is 3,6-Dichloropyridazine, introducing its new discovery. COA of Formula: C4H2Cl2N2

Under suitable thermal or basic conditions pyridazinylhydrazones are transformed t o the desmotropic pyridazinylpyrezolinones, the structure of which was proven by al kylation and ecylation.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1915 – PubChem