1120-95-2, Name is 3-Chloropyridazine, belongs to pyridazine compound, is a common compound. Quality Control of 3-ChloropyridazineIn an article, once mentioned the new application about 1120-95-2.
A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by replacing the thiazole with a thiadiazole. Potency in the series was improved by modifying the substituents on the pyrimidine and/or on the thiazole or thiadiazole pendant aryl ring. In vivo examination revealed that compounds from the series are not highly bioavailable. This is attributed to low solubility and poor permeability.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N431 – PubChem