141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 3,6-DichloropyridazineIn an article, once mentioned the new application about 141-30-0.
A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549 cell line with the half maximal inhibitory concentration (IC50) value of 1.48 muM, which was a more potent inhibitor than cisplatin (IC50 = 12.08 muM) and leading compound 2 (IC50 = 1.69 muM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a?d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased DeltaTm values from 12.44 to 20.54 C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549 cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1796 – PubChem