Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 65202-50-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 65202-50-8, in my other articles.
One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 65202-50-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, molecular formula is C6H5ClN2O2
A series of N--2-butylimidazoles containing variously substituted diazine or pyridine moieties either as their free bases or N-oxide derivatives attached to the 4-position of the imidazole ring was synthesized and tested for interaction with the AT1 receptors of the rat adrenal cortex membranes (receptor binding assay).Some compounds were then chosen for further evaluation in vivo in the A II-induced pressor response in conscious normotensive rats.The most potent in the AT1 binding assay were found to be compounds in which the diazine or pyridine ring nitrogen is adjacent to the point of attachment between the two heteroaromatic rings such as 2-butyl-4-(3,6-dimethylpyrazin-2-yl)-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-imidazole (3b) or 2-butyl-4-<5-(methoxycarbonyl)pyrid-2-yl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-imidazole (6c).The binding affinities and oral activities of the pyridine N-oxide imidazoles in which a stabilizing group ortho to the pyridine ring nitrogen is present were markedly improved as in 2-butyl-4-<(3-methoxycarbonyl)-6-methyl-N-oxopyridin-2-yl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-imidazole 31b.Molecular modeling studies were carried out to determine the molecular electrostatic potential values of related model systems and to correlate their receptor interaction energies with the observed activities of our compounds.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 65202-50-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 65202-50-8, in my other articles.
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2432 – PubChem