In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 141-30-0, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 141-30-0, name is 3,6-Dichloropyridazine. In an article，Which mentioned a new discovery about 141-30-0
Using molecular modeling and rationally designed structural modifications, the multi-target structure?activity relationship for a series of ranitidine analogs has been investigated. Incorporation of a variety of isosteric groups indicated that appropriate aromatic moieties provide optimal interactions with the hydrophobic and pi?pi interactions with the peripheral anionic site of the AChE active site. The SAR of a series of cyclic imides demonstrated that AChE inhibition is increased by additional aromatic rings, where 1,8-naphthalimide derivatives were the most potent analogs and other key determinants were revealed. In addition to improving AChE activity and chemical stability, structural modifications allowed determination of binding affinities and selectivities for M1?M4 receptors and butyrylcholinesterase (BuChE). These results as a whole indicate that the 4-nitropyridazine moiety of the JWS-USC-75IX parent ranitidine compound (JWS) can be replaced with other chemotypes while retaining effective AChE inhibition. These studies allowed investigation into multitargeted binding to key receptors and warrant further investigation into 1,8-naphthalimide ranitidine derivatives for the treatment of Alzheimer’s disease.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 141-30-0, help many people in the next few years.Product Details of 141-30-0
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1702 – PubChem