One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 4,5-Dichloro-3(2H)-pyridazinone, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O
A series of new pyridazin-3(2H)-one derivatives (3 and 4) were evaluated for their in vitro affinity toward both alpha1- and alpha2-adrenoceptors by radioligand receptor binding assays. All target compounds showed good affinities for the alpha1-adrenoceptor, with Ki values in the low nanomolar range. The polymethylene chain constituting the spacer between the furoylpiperazinyl pyridazinone and the arylpiperazine moiety was shown to influence the affinity and selectivity of these compounds. Particularly, a gradual increase in affinity was observed by lengthening the polymethylene chain up to a maximum of seven carbon atoms. In addition, compound 3k, characterized by a very interesting alpha1-AR affinity (1.9 nM), was also shown to be a highly selective alpha1-AR antagonist, the affinity ratio for alpha2- and alpha1-adrenoceptors being 274. To gain insight into the structural features required for alpha1 antagonist activity, the pyridazinone derivatives were submitted to a pharmacophore generation procedure using the program Catalyst. The resulting pharmacophore model showed high correlation and predictive power. It also rationalized the relationships between structural properties and biological data of, and external to, the pyridazinone class.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2292 – PubChem