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Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-beta, and can be used to treat disease by blocking TGF-beta signaling.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N27 – PubChem