Brief introduction of 4,5-Dibromopyridazin-3(2H)-one

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Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3164 – PubChem

 

Archives for Chemistry Experiments of 3-Chloro-6-iodopyridazine

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The present invention relates to ethynyl derivatives of formula (I) as allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5). The variables in formula (I) are defined in the specification.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3049 – PubChem

 

Extended knowledge of 41933-33-9

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The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3191 – PubChem

 

Some scientific research about 3,6-Dichloropyridazine

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Related Products of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1639 – PubChem

 

Some scientific research about 3,6-Dichloropyridazine

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 141-30-0, name is 3,6-Dichloropyridazine, introducing its new discovery. Recommanded Product: 141-30-0

The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1280 – PubChem

 

The Absolute Best Science Experiment for 3,6-Dichloropyridazine

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Electric Literature of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article,once mentioned of 141-30-0

For the first time, heterogeneous osmium tetroxide catalyzed asymmetric aminohydroxylation of olefins on polymer-supported ligands have been shown to proceed with comparable rate as in the case of homogeneous conditions.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1835 – PubChem

 

Archives for Chemistry Experiments of 141-30-0

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Cyclic voltammetry and controlled-potential electrolysis have been employed to examine the electrochemical behavior of some mono- and dichlorinated pyrazines, quinoxalines, and pyridazines at carbon and mercury cathodes in either acetonitrile or dimethylformamide containing a tetraalkylammonium salt. Unsubstituted pyrazine and pyridazine each exhibit a single reduction wave, whereas unsubstituted quinoxaline shows three cathodic waves. For the chlorinated compounds, an additional wave is seen for the reduction of each carbon-chlorine bond. Depending on the potential of the cathode, bulk electrolyses of dichlorinated pyrazines or quinoxalines afford either the monochlorinated or fully dechlorinated product, whereas the monochlorinated analogues undergo reduction to the dechlorinated species. Electrolyses of chlorinated pyridazines give dark colored solutions, but the products (apparently polymeric) cannot be detected or identified by means of conventional GC, GC-MS, and HPLC techniques.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1829 – PubChem

 

Awesome Chemistry Experiments For 3-Aminopyridazine

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Application of 5469-70-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3. In a article,once mentioned of 5469-70-5

A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed, which involved the regio- and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H-imidazol-2-yl)acetamide 2.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N101 – PubChem

 

Awesome Chemistry Experiments For Pyridazine-3-carbonitrile

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Electric Literature of 53896-49-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.53896-49-4, Name is Pyridazine-3-carbonitrile, molecular formula is C5H3N3. In a article,once mentioned of 53896-49-4

Irradiation of 9 leads to hydrogen abstraction by N(1) and fragmentation to 8 from a triplet with ET ?78 kcal/mol. Irradiation of 2-acylpyridines (10) leads to abstraction by both nitrogen and oxygen (cf. eq 4), with the same Stern-Volmer kqtau for the two processes. Irradiation of 2-acylpyrazines (11) can lead to abstraction by either nitrogen (phi27 0.77 from 11b) or oxygen (phi11a 0.95 from 11f)- 3-Acylpyridazine 12d is unreactive on direct irradiation or triplet sensitization with sensitizer ET ?70 kcal/mol; it furnishes a small amount of 12a on sensitization by acetone. Ketone 18 is recovered unchanged from irradiation under all conditions used with 12d. These observations suggest a correlation between the photochemistry of each of these compounds and the energy of the npi* triplet of the heteroaromatic ring. The nature of the excited state(s) responsible for hydrogen abstraction by nitrogen and oxygen in these ketones is discussed.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N197 – PubChem

 

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A process is described for the production of cyclohexanedimethanol by hydrogenation of a dialkyl cyclohexanedicarboxylate which comprises the steps of: (a) providing a hydrogenation zone containing a charge of a granular reduced manganese promoted copper catalyst; (b) forming a vaporous feed stream of a hydrogenatable material comprising a dialkyl cyclohexanedicarboxylate and from about 0.1 wt % up to about 15 wt % of an acidic material at a feed temperature which is in the range of from about 150 C. to about 350 C. and which is above the dew point of the feed stream and at a feed pressure which is in the range of from about 150 psia (about 10.34 bar) up to about 2000 psia (about 137.90 bar), said vaporous mixture having a known hydrogen-containing gas:dialkyl cyclohexanedicarboxylate ratio; (c) supplying the vaporous feed stream to the hydrogenation zone; (d) maintaining hydrogenation conditions in the hydrogenation zone which are effective to maintain the reaction mixture in contact with the catalyst above its dew point; (e) passing the vaporous feed stream through the hydrogenation zone: and (f) recovering from the hydrogenation zone a product stream comprising cyclohexanedimethanol.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2083 – PubChem