932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, belongs to pyridazine compound, is a common compound. COA of Formula: C4H2Cl2N2OIn an article, once mentioned the new application about 932-22-9.
In continuing our search for selective alpha(1)-adrenoceptor (AR) antagonists, we have synthesized new alkoxyarylpiperazinylalkylpyridazinone derivatives. The new compounds were tested for their affinity toward alpha(1)- and alpha(2)-AR and toward the 5-HT(1A) receptor. alpha(1)-AR affinity data are in the subnanomolar range, with 3 showing an affinity of 0.052 nM, about 5-fold higher than prazosin. None of the studied compounds was found to be alpha(1)/alpha(2) selective, but 8 showed an interesting 5-HT(1A)/alpha(1) affinity ratio of 119.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2294 – PubChem