115514-66-4, Name is 4-Bromopyridazine, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 115514-66-4.
SAR of a novel series of pyridine-derived gamma-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42 and Abeta40, and maintain (or increase) the levels of total Abeta. Furthermore, representative compounds 1 and 5 demonstrated in vivo efficacy to lower Abeta42 in the brain without altering Notch processing in the peripheral.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2119 – PubChem