One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 4-Bromo-6-chloro-2-methylpyridazin-3(2H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1178884-53-1, Name is 4-Bromo-6-chloro-2-methylpyridazin-3(2H)-one, molecular formula is C5H4BrClN2O
Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling, downstream of activated RAS, and the poor overall kinase selectivity of putative RAF inhibitors. Herein, we describe 15 (LXH254, Aversa, R.; et al. Int. Patent WO2014151616A1, 2014), a selective B/C RAF inhibitor, which was developed by focusing on drug-like properties and selectivity. Our previous tool compound, 3 (RAF709; Nishiguchi, G. A.; et al. J. Med. Chem. 2017, 60, 4969), was potent, selective, efficacious, and well tolerated in preclinical models, but the high human intrinsic clearance precluded further development and prompted further investigation of close analogues. A structure-based approach led to a pyridine series with an alcohol side chain that could interact with the DFG loop and significantly improved cell potency. Further mitigation of human intrinsic clearance and time-dependent inhibition led to the discovery of 15. Due to its excellent properties, it was progressed through toxicology studies and is being tested in phase 1 clinical trials.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of 4-Bromo-6-chloro-2-methylpyridazin-3(2H)-one, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1178884-53-1
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3004 – PubChem