One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: pyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2164-61-6, Name is Pyridazine-3-carboxylic acid, molecular formula is C5H4N2O2
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and therefore a rational target for chemotherapeutic intervention in the treatment of HIV-1 infection. We report here the discovery of Raltegravir, the first HIV-integrase inhibitor approved by FDA for the treatment of HIV infection. It derives from the evolution of 5,6-dihydroxypyrimidine-4-carboxamides and N-methyl-4- hydroxypyrimidinone-carboxamides, which exhibited potent inhibition of the HIV-integrase catalyzed strand transfer process. Structural modifications on these molecules were made in order to maximize potency as HIV-integrase inhibitors against the wild type virus, a selection of mutants, and optimize the selectivity, pharmacokinetic, and metabolic profiles in preclinical species. The good profile of Raltegravir has enabled its progression toward the end of phase III clinical trials for the treatment of HIV-1 infection and culminated with the FDA approval as the first HIV-integrase inhibitor for the treatment of HIV-1 infection.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. category: pyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2164-61-6, in my other articles.
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N498 – PubChem