65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, belongs to pyridazine compound, is a common compound. Recommanded Product: 65202-50-8In an article, once mentioned the new application about 65202-50-8.
Potent and orally bioavailable SCD inhibitors built on an azetidinyl pyridazine scaffold were identified. In a one-month gDIO mouse model of obesity, we demonstrated that there was no therapeutic index even at low doses; efficacy in preventing weight gain tracked closely with skin and eye adverse events. This was attributed to the local SCD inhibition in these tissues as a consequence of the broad tissue distribution observed in mice for this class of compounds. The search for new structural scaffolds which may display a different tissue distribution was initiated. In preparation for an HTS campaign, a radiolabeled azetidinyl pyridazine displaying low non-specific binding in the scintillation proximity assay was prepared.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2433 – PubChem