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This paper describes a modified method of preparation of a number of alpha-aryl-alpha-(pyridazin-3-yl)-acetonitriles via the C-arylation reaction of the corresponding carbanions of phenylacetonitriles using 3-chloropyridazine derivatives. KOH and DMSO were used in the deprotonation process, which made the reaction very simple and safe to perform. Nitriles were obtained in the hydrolysis reaction to the corresponding alpha-aryl-alpha-(pyridazin-3-yl)- acetamide derivatives, which were next subjected to cyclization to afford the final products. A number of new derivatives of 7H,8H-pyrimido[1,6-b]pyridazin-6, 8-dione were synthesized in the cyclocondensation reaction of respective alpha-aryl-alpha-(pyridazin-3-yl)-acetamides with diethyl carbonate in the presence of EtONa. The structure and composition of the new compounds were confirmed by IR, 1H- and 13C- NMR analyses and by elemental C, H and N analysis.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 141-30-0, you can also check out more blogs about141-30-0
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1731 – PubChem