Synthetic Route of 5469-70-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 5469-70-5, molcular formula is C4H5N3, introducing its new discovery.
In this work, a series of 2-substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamide derivatives were developed as beta-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. In addition, the selected compounds were tested with affinity (KD) towards BACE-1, blood brain barrier (BBB) permeability and cytotoxicity. The studies revealed that the most potent analog 41 (IC50 = 4.6 muM) with high predicted BBB permeability and low cellular cytotoxicity, could serve as a good lead structure for further optimization.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5469-70-5 is helpful to your research. Synthetic Route of 5469-70-5
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N100 – PubChem