Electric Literature of 34584-69-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 34584-69-5, Name is 3,6-Dichloro-4,5-dimethylpyridazine,introducing its new discovery.
The merger of decatungstate and copper catalysis to enable aliphatic C(sp 3)?H trifluoromethylation
The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound?s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C?H bonds remain elusive. Here we report the development of a dual-catalytic C(sp3)?H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C?H bonds into the corresponding C(sp3)?CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ?Cu?CF3? species is formed during this process and the critical C(sp3)?CF3 bond-forming step involves the copper catalyst. [Figure not available: see fulltext.].
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 34584-69-5, and how the biochemistry of the body works.Electric Literature of 34584-69-5
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2475 – PubChem