Month: April 2021

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 35857-89-7, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 35857-89-7, name is 6-Chloropyridazine-3-carbonitrile. In an article，Which mentioned a new discovery about 35857-89-7

Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. II. Synthesis and structure-activity relationships of 4,5,6,7-tetrahydro-1H-benzimidazole derivatives

A novel series of 4,5,6,7-tetrahydro-1H-benzimidazole derivatives 4, 5, 6 and 7 was prepared and evaluated for activities as 5-hydroxytryptamine (5- HT3) receptor antagonists which may be useful for the treatment of irritable bowel syndrome (IBS) as well as nausea and vomiting associated with cancer chemotherapy. These compounds were designed by modifying the aromatic- carbonyl part of N-(2-methoxyphenyl)-4,5,6,7-tetrahydro-1H-5- benzimidazolylcarboxamide 3, leaving the imidazole moiety unchanged as the amine part. The indole derivatives 7d, g, h and indolizine derivatives 7k, 1 were found to be highly potent on the von Bezold-Jarisch (B.J.) reflex test with ID50 values of below 0.1 mug/kg, and the indoline derivative 6c, indole derivatives 7a, d, g, benzofurane derivative 7j and indolizine derivative 7k were observed to be very potent on the colonic contraction with IC50 values of below 0.1 muM. In particular, 71 was the most potent on the B.J. reflex (ID50 = 0.018 mug/kg), approximately 200 and 50 times more potent than ondansetron 1 and granisetron 2, and 7k was the most potent on the colonic contraction (IC50 = 0.011 muM), approximately 70 and 6 times more potent than 1 and 2, respectively.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N957 – PubChem

 

Application of 4578-58-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4578-58-9, Name is 6-Methyl-2-phenyl-4,5-dihydropyridazin-3(2H)-one, molecular formula is C11H12N2O. In a Article，once mentioned of 4578-58-9

A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones

(Equation presented) A general method was developed for the one-pot synthesis of highly functionalized indoles from simple, commercially available aryl hydrazines and cyclic enol ethers. Enol lactones were also used as substrates, affording substituted indole acetic acid or indole propionic acid derivatives. This procedure affords 2,3-disubstituted indoles as single regioisomers from the appropriately substituted enol ether or enol lactone. This method was highlighted in the efficient synthesis of the antimigraine drug sumitriptan and the antiinflammatory drug indomethacin.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2539 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C4H2Cl2N2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2

6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS

A TARP ?8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is; and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1322 – PubChem

 

Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article，once mentioned of 141-30-0

SRN1 Mechanism in Heteroaromatic Nucleophilic Substitution. Reactions Involving Certain Dihalogenated ?-Deficient Nitrogen Heterocycles

Photostimulated reactions of 2,6-,2,3-, 3,5-, and 2,5-dihalopyridines (1a-e) with pinacolone potassium enolate (2) in liquid NH3 lead to facile replacement of both halogens via a modified SRN1 mechanism, which does not involve intermediate formation of monosubstitution products.The potassium salts of phenylacetonitrile (12a) and alpha-ethylphenylacetonitrile (12b) react with 2,6-dibromopyridine (1a) under similar conditions to afford a mixture of mono- and disubstituted products via a related SRN1 process. 4,7-Dichloroquinoline (16) undergoes radical-chain displacement of chloride from C4 with enolate 2. 2,6-Dichloropyrazine (18) and 2,3-dichloropyrazine (20) also undergo monosubstitution with 2 and diisopropyl ketone potassium enolate (22), but these reactions appear to be mainly addition-elimination (SNAr) processes.Treatment of 3,6-dichloropyridazine (27) with 22 results in addition of 22 to C4 of the substrate.Photoassisted reaction of 2,4-dichloropyrimidine (31) with 12a leads to exclusive chloride displacement from C4 via the SRN1 mechanism.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1637 – PubChem

 

Related Products of 35857-89-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 35857-89-7, 6-Chloropyridazine-3-carbonitrile, introducing its new discovery.

Production Method of Nitrogen-Containing Fused Ring Compounds

[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like. [Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained. wherein each symbol is as defined in the description.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N859 – PubChem

 

Synthetic Route of 1837-55-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1837-55-4, Name is 3,5-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent，once mentioned of 1837-55-4

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1134 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 4,5-Dichloro-3(2H)-pyridazinone, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 932-22-9

Pyridazines with Heteroatom Substituents in Position 3 and 5, Part 1: 5-Hydroxy-3(2H)-pyridazinone and Its Derivatives

The synthesis of the title compound 7 was achieved starting with mucochloric acid via the pyridazinones 1,2 and 6.The electrolytic ionisation constants for 7 were found to be 4.81 (+/-0.03) and -0.3 (+/-0.3).Crystal structure analyses were performed for 7 and its “fixed” derivatives 6 and 9. – Keywords.Synthesis of 5-methoxy- and 5-hydroxy-3(2H)-pyridazinones; pKa Values of 5-hydroxy-3(2H)-pyridazinone; Crystal structure of 3(2H)-pyridazinones.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2372 – PubChem

 

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Formula: C4H2Cl2N2In an article, once mentioned the new application about 141-30-0.

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson’s disease (PD). The most common mutant, G2019S, increases kinase activity, thus LRRK2 kinase inhibitors are potentially useful in the treatment of PD. We herein disclose the structure, potential ligand-protein binding interactions, and pharmacological profiling of potent and highly selective kinase inhibitors based on a triazolopyridazine chemical scaffold.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1699 – PubChem

 

Application of 1121-79-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1121-79-5, Name is 3-Chloro-6-methylpyridazine, molecular formula is C5H5ClN2. In a Patent，once mentioned of 1121-79-5

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound having a good agonistic activity to melanocortin receptor, or pharmaceutically acceptable salt or isomer thereof, and an agonistic composition for melanocortin receptor comprising the same as an active ingredient

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N594 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C4H5N3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3

IMIDAZOLE DERIVATIVE

The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1.The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compound.The invention further relates to a composition comprising an imidazole derivative as described above, or a pharmaceutically-suitable acid-addition salt thereof, and to processes for preparing such compounds.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N22 – PubChem