Month: April 2021

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C3H2F6O, 920-66-1, Name is 1,1,1,3,3,3-Hexafluoropropan-2-ol, SMILES is OC(C(F)(F)F)C(F)(F)F, belongs to pyridazines compound. In a document, author is Fan, Hongli, introduce the new discover.

Convenient two-step one-pot synthesis of 3-substituted imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines

A convenient and novel two-step one-pot method for the synthesis of 3-substituted imidazo[1,2-a]pyridines and 3-substituted imidazo[1,2-b]pyridazines was developed through the reaction of heterocyclic amines and N, N-dimethylformamide dimethyl acetate with active electrophiles RCH2Br (R = CO2Et, CN, COPh, 4′-MeO-PhCO and 4′-F-PhCO). This protocol provides a simple and practical approach to 3-substituted fused imidazo-heterocyclic compounds in moderate to high yields.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 920-66-1. Formula: C3H2F6O.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a document, author is Elmeligie, Salwa, introduce the new discover, Category: pyridazines.

Design and Synthesis of Pyridazine Containing Compounds with Promising Anticancer Activity

Certain pyridazine containing compounds 2a-f, 3a, b, 4a, b, 5a, b, 6a and b were synthesized and characterized by spectroscopic means and elemental analysis. All the synthesized compounds were screened for their cytotoxic activity in vitro on colon cancer cell line (HCT-116) and breast cancer cell line (MCF-7). In addition, the antitumor activity of the synthesized compounds was tested in vivo against Ehrlich’s ascites carcinoma (EAC) solid tumor grown in mice. The in vitro vascular endothelial growth factor receptor (VEGFR) enzyme inhibition assay was carried out for the most active compounds at a single dose of 10 mu m. The obtained results revealed that compound 5b, which showed potent cytotoxic activity against HCT-116 also, exhibited the highest inhibition in the VEGFR kinase assay (92.2%).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2605-67-6 is helpful to your research. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C4H4ClN3, 5469-69-2, Name is 3-Amino-6-chloropyridazine, molecular formula is C4H4ClN3, belongs to pyridazines compound. In a document, author is Saquib, Mohammad, introduce the new discover.

Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment

The emergence of drug resistance, coupled with the issue of low tumor selectivity and toxicity is a major pitfall in cancer chemotherapy. It has necessitated the urgent need for the discovery of less toxic and more potent new anti-cancer pharmaceuticals, which target the interactive mechanisms involved in division and metastasis of cancer cells. Human DNA ligase I (hligI) plays an important role in DNA replication by linking Okazaki fragments on the lagging strand of DNA, and also participates in DNA damage repair processes. Dysregulation of the functioning of such ligases can severely impact DNA replication and repair pathways events that are generally targeted in cancer treatment. Although, several human DNA ligase inhibitors have been reported in the literature but unfortunately not a single inhibitor is currently being used in cancer chemotherapy. Results of pre-clinical studies also support the fact that human DNA ligases are an attractive target for the development of new anticancer agents which work by the selective inhibition of rapidly proliferating cancer cells. In this manuscript, we discuss, in brief, the structure, synthesis, structure-activity-relationship (SAR) and anticancer activity of recently reported hLigI inhibitors. (C) 2019 Elsevier Masson SAS. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5469-69-2. Formula: C4H4ClN3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 375-72-4, Name is 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride, molecular formula is C4F10O2S. In an article, author is Ghazoui, A.,once mentioned of 375-72-4, SDS of cas: 375-72-4.

The study of the effect of ethyl (6-methyl-3-oxopyridazin-2-yl) acetate on mild steel corrosion in 1M HCl

In this work, we are interested in studying the effect of the addition of a heterocyclic organic compound derived from pyridazine named ethyl (6-methyl-3-oxopyridazin-2-yl) acetate (GK2) on inhibition of the corrosion of mild steel (C38) in a molar hydrochloric acid solution. This study was performed using the method of weight loss, potentiodynamic polarization and the electrochemical impedance spectroscopy (EIS). Gravimetric measurements indicate that the inhibitor has GK2 efficiency increases with the concentration to reach a maximum value of 83.1% at 10(-3) M. In addition, studies revealed that the potentiodynamic polarization act as a mixed inhibitor with predominance at cathodic domain. EIS shows that increasing the concentration of the inhibitor leads to an increase of the charge transfer resistance and reducing the double layer capacitance. Effect of temperature was studied between 308 and 343 K and determination of adsorption and activation parameters is also discussed. (C) 2016 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 375-72-4, SDS of cas: 375-72-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, Safety of 4-Pyridazinecarboxylic Acid, begins with the direct observation of nature¡ª in this case, of matter.50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a document, author is Bin Rus, Yahdi, introduce the new discover.

Electrodeposition of Silver Nanoparticles on Reduced Graphene Functionalized by Pyridine-Pyridazine Units: Application to Surface-Enhanced Raman Spectroscopy and Electrocatalysis

A new and versatile method to prepare Ag nanoparticles on functionalized graphene sheets is described. In a first step, pyridine-pyridazine units are introduced on graphene sheets by cycloaddition reaction with a tetrazine derivative. Then the material is coated on an electrode and electrodeposition is carried out to generate silver nanoparticles in a one-step electroreduction process. The applied potential signal is shown to influence the size and dispersity of the particles in the composite. While larger particles are active in improving sensitivity of Surface-Enhanced Raman Spectroscopy, smaller ones can be efficiently used in electrocatalysis, like for oxygen reduction. Both effects are demonstrated to highlight the versatility of the applications of these easily prepared nanocomposites.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 50681-25-9. Safety of 4-Pyridazinecarboxylic Acid.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 19430-93-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19430-93-4, Name is 3,3,4,4,5,5,6,6,6-Nonafluorohex-1-ene, SMILES is C=CC(F)(F)C(F)(F)C(F)(F)C(F)(F)F, belongs to pyridazines compound. In a article, author is Wei, Liang, introduce new discover of the category.

Enantioselective synthesis of multi-nitrogen-containing heterocycles using azoalkenes as key intermediates

Chiral multi-nitrogen-containing heterocycles, such as pyrazole, imidazole and pyridazine, are widely found in naturally occurring organic compounds and pharmaceuticals, and hence, their stereoselective and efficient synthesis is an important issue in organic synthesis. Out of the variety of methods that have been developed over the past century, the catalytic asymmetric cyclization and cycloaddition reactions are recognized as the most synthetically useful strategies due to their step-, atom-and redox-economic nature. In particular, the recently developed annulation reactions using azoalkenes as key intermediates show their great ability to construct diverse types of multi-nitrogen-containing heterocycles. In this feature article, we critically analyse the strategic development and the efficient transformation of azoalkenes to chiral heterocycles and alpha-functionalized ketone derivatives since 2010. The plausible mechanism for each reaction model is also discussed.

Electric Literature of 19430-93-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 19430-93-4 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 5469-69-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a article, author is Bayat, Mohammad, introduce new discover of the category.

An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

A convenient one-pot protocol was developed for the synthesis of spiro[indeno[2,1-c]pyridazine-9,4′-pyran]-3′,4-dicarbonitrile derivatives by the reaction of cyanoacetohydrazide, ninhydrin, malononitrile and various cyclic CH-acids under reflux condition in ethanol. No hazardous solvent or catalyst was used in this method. The main advantages of this procedure are the availability of starting materials, very high yields and easy purification.

Synthetic Route of 5469-69-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5469-69-2 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Pluta, Krystian, once mentioned the application of 5469-69-2, Safety of 3-Amino-6-chloropyridazine, Name is 3-Amino-6-chloropyridazine, molecular formula is C4H4ClN3, molecular weight is 129.5477, MDL number is MFCD00051506, category is pyridazines. Now introduce a scientific discovery about this category.

Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties

For the last two decades, classical phenothiazines have attracted attention of researchers, as the hitherto investigations have revealed many significant biological activities within this class of compounds, other than originally discovered neuroleptic ones. Important, new pharmaceutical results on phenothiazines, as 10-substituted dibenzothiazines, were recently highlighted in several reviews. Azaphenothiazines are structurally modified phenothiazines by substitution of one or both benzene rings in the phenothiazine ring system with the azine rings, such as: pyridine, pyridazine, pyrimidine, pyrazine, 1,2,4-triazine, quinoline, quinoxaline, benzoxazine and benzothiazine. They form over 50 different heterocyclic systems, of tri-, tetra-, penta- and hexacyclic structures, and contain from one to even four azine nitrogen atoms. This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in vivo. It describes, in addition, current trends in the synthesis of azaphenothiazines. The influence of the azaphenothiazine ring system, the nature of the substituents, predominantly at the thiazine nitrogen atom, as well as at the azine nitrogen atom and carbon atom, on the biological activities, were also discussed. (C) 2017 Elsevier Masson SAS. All rights reserved.

If you are interested in 5469-69-2, you can contact me at any time and look forward to more communication. Safety of 3-Amino-6-chloropyridazine.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1799-84-4, Name is 3,3,4,4,5,5,6,6,6-Nonafluorohexyl methacrylate, molecular formula is C10H9F9O2. In an article, author is Chen, Man,once mentioned of 1799-84-4, SDS of cas: 1799-84-4.

Highly efficient solution processed OLEDs based on iridium complexes with steric phenylpyridazine derivative

Four bis-cyclometalated iridium complexes (Ir(tpp)(2)(pic) (1), Ir(tpp)(2)(paz) (2), Or(ttp)(2)(pic) (3) and Or (ttp)(2)(paz) (4) with phenylpyridazine derivative ligands were synthesized under mild reaction conditions, in which tpp (tppH = 3, 6-bis(4- (trifluoromethyl)phenyl)pyridazine) or ttp (ttpH = (5 s, 8 s)-1,4-bis(4- (trifluommethyl))-diphenyl-5,6,7,8-tetrahydro-5,8-thanophthalazine) was used as the primary ligand and pyridine2-carboxylate (pic) or paz (pazH = 2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine) were used as ancillary ligand. The coordination arrangement of complexes 1-3 was revealed by the single X-ray structural analyses. All complexes showed strong emissions with peaks ranged from 519 to 547 nm and quantum efficiencies of 0.55-0.80. By introducing sterically hindered bicyclo [2.2.2] oct-2-ene groups in the primary ligands of complexes 3 and 4, their molecular interactions are strongly restrained in solid. The organic light-emitting diodes (OLEDs) were fabricated with complexes 2 (device A) and 4 (device B) as dopants. The better device performances with a maximum current efficiency of 50.5 cd A(-1) and a maximum external quantum efficiency of 14.9% are achieved by device B, along with smaller efficiency roll-off, which is attributed to the effect of alkyl steric groups and relative more matched energy levels in device.

Interested yet? Keep reading other articles of 1799-84-4, you can contact me at any time and look forward to more communication. SDS of cas: 1799-84-4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

4949-44-4, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, COA of Formula: C7H12O3, belongs to pyridazines compound, is a common compound. In a patnet, author is Rozen, Shlomo, once mentioned the new application about 4949-44-4.

Synthesis of N,N-Dioxopyridazines

Despite many efforts, one of the smallest heterocycles containing two nitrogen atoms, pyridazine, could not be converted to its N,N-dioxide (see, however, Nakaate et at Chem. Pharm. Bull. 1970, 18, 1211-1218). HOF. CH3CN, made easily from diluted fluorine, was able to accomplish this task in a fast reaction with good yields.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4949-44-4 help many people in the next few years. COA of Formula: C7H12O3.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem