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Pyridazines. LII. Novel 1,2-Diazine Analogues of 2-Aminobenzophenone via Directed Lithiation

The preparation of novel pyridazine analogues of 2-aminobenzophenone, namely 2-(substituted)aminophenyl 3-pyridazinyl ketones 2, 3, 4a,b, achieved by reaction of methyl 3-pyridazinecarboxylate with ortho-lithiated aniline derivatives, is reported.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N784 – PubChem

 

Brief introduction of 5-Bromo-6-phenylpyridazin-3(2H)-one

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Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)- pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N3125 – PubChem

 

Brief introduction of 3,6-Dichloropyridazine

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Novel diazine derivatives

The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1236 – PubChem

 

Some scientific research about 6-Iodopyridazin-3-amine

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187973-60-0, Name is 6-Iodopyridazin-3-amine, belongs to pyridazine compound, is a common compound. Computed Properties of C4H4IN3In an article, once mentioned the new application about 187973-60-0.

PYRROLIDINO HETEROCYCLES

The invention relates to compounds of formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2931 – PubChem

 

Awesome and Easy Science Experiments about 88491-61-6

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Pyridazines by addition of diazoalkanes to 1-bromo- and 1,2- dibromocyclopropenes

Reaction of a range of 1-bromocyclopropenes with diazo-compounds leads to pyrazoles which ring-open to pyridazines in reasonable yield.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2138 – PubChem

 

New explortion of Methyl 6-chloropyridazine-3-carboxylate

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Synthetic Route of 65202-50-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 65202-50-8, molcular formula is C6H5ClN2O2, introducing its new discovery.

3 (3-Pyrimidin-2-ylbenzyl)-1,2,4-triazolo[4,3-b]pyridazine derivatives

Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2407 – PubChem

 

Final Thoughts on Chemistry for 3-Phenyl-6-chloropyridazine

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Three-step synthesis of cyclopropyl peptidomimetics

An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2618 – PubChem

 

The Absolute Best Science Experiment for 20744-39-2

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Reference of 20744-39-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3. In a Patent,once mentioned of 20744-39-2

4-Methylsulfonyl-Substituted Piperidine Urea Compounds

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N132 – PubChem

 

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Application of 7145-60-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 7145-60-0, Name is 6-Chloro-N,N-dimethylpyridazin-3-amine,introducing its new discovery.

Optimization of a series of multi-isoform PI3 kinase inhibitors

Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2033 – PubChem

 

Archives for Chemistry Experiments of 3,6-Dichloropyridazine

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Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents

A series of nicotinic acid derivatives structurally related to niflumic acid and certain pyridazine-containing compounds have been synthesized and characterized by analytical and spectral data. All compounds were screened for their potential analgesic and anti-inflammatory activities. The compounds which displayed analgesic and anti-inflammatory activities were tested for ulcerogenicity and screened for in vivo inhibition of certain inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2). Compounds 1c, 2a, 2b, and 5a have shown potent analgesic and anti-inflammatory activities.

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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N1586 – PubChem