141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Formula: C4H2Cl2N2In an article, once mentioned the new application about 141-30-0.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold
Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson’s disease (PD). The most common mutant, G2019S, increases kinase activity, thus LRRK2 kinase inhibitors are potentially useful in the treatment of PD. We herein disclose the structure, potential ligand-protein binding interactions, and pharmacological profiling of potent and highly selective kinase inhibitors based on a triazolopyridazine chemical scaffold.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1699 – PubChem