10071-38-2, Name is 6-Chloro-2-methylpyridazin-3(2H)-one, belongs to pyridazine compound, is a common compound. Recommanded Product: 10071-38-2In an article, once mentioned the new application about 10071-38-2.
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11beta hydroxysteroid dehydrogenase type 1 inhibitor
A potent, in vivo efficacious 11beta hydroxysteroid dehydrogenase type 1 (11beta HSD1) inhibitor (11j) has been identified. Compound 11j inhibited 11beta HSD1 activity in human adipocytes with an IC50 of 4.3 nM and in primary human adipose tissue with an IC80 of 53 nM. Oral administration of 11j to cynomolgus monkey inhibited 11beta HSD1 activity in adipose tissue. Compound 11j exhibited >1000× selectivity over other hydroxysteroid dehydrogenases, displays desirable pharmacodynamic properties and entered human clinical trials in 2011.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1126 – PubChem