A new application about 20744-39-2

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of Pyridazin-4-amine, you can also check out more blogs about20744-39-2

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of Pyridazin-4-amine. Introducing a new discovery about 20744-39-2, Name is Pyridazin-4-amine

5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy

We describe the discovery and optimization of 5-substituted-N-pyridazinylbenzamide derivatives as potent and selective LRRK2 inhibitors. Extensive SAR studies led to the identification of compounds 18 and 23, which demonstrated good in vitro pharmacokinetic profile and excellent selectivity over 140 other kinases. Both compounds demonstrated high unbound fractions in both blood and brain. Compound 18 proved to be brain penetrant, and the high unbound fraction of compound 18 in brain enabled its in vivo efficacy in CNS, wherein a significant inhibition of LRRK2 Ser935 phosphorylation was observed in rat brain following intravenous infusion at 5 mg/kg/h.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of Pyridazin-4-amine, you can also check out more blogs about20744-39-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N153 – PubChem