One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Pyridazine-3-carbonitrile, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 53896-49-4, Name is Pyridazine-3-carbonitrile, molecular formula is C5H3N3
C?H Cyanation of 6-Ring N-Containing Heteroaromatics
Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Pyridazine-3-carbonitrile, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53896-49-4, in my other articles.
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N192 – PubChem