1120-95-2, Name is 3-Chloropyridazine, belongs to pyridazine compound, is a common compound. name: 3-ChloropyridazineIn an article, once mentioned the new application about 1120-95-2.
Synthesis and SAR of a new series of COX-2-selective inhibitors: Pyrazolo[1,5-alpha]pyrimidines
The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-alpha]pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema and air-pouch model). Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6,7-dimethyl-2-(4-methylsulfonylphenyl) pyrazolo[1,5-alpha]pyrimidine (10f) as one of the most potent and selective COX-2 inhibitor in this series.
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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N407 – PubChem