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Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol
A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 6-Chloropyridazine-3-carbonitrile, you can also check out more blogs about35857-89-7
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1001 – PubChem