One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 4-Bromopyridazine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 115514-66-4, Name is 4-Bromopyridazine, molecular formula is C4H3BrN2
Aminothiazoles as gamma-secretase modulators
We herein report the discovery of a new gamma-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These novel compounds demonstrate moderate to good in vitro potency in inhibiting amyloid beta (Abeta) peptide production. Overall c-secretase is not inhibited but the formation of the aggregating, toxic Abeta42 peptide is shifted to smaller non-aggregating Ab peptides. Compound 15 reduced brain Abbeta42 in vivo in APPSwe transgenic mice at 30 mg/kg p.o.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 4-Bromopyridazine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 115514-66-4, in my other articles.
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2117 – PubChem