35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 35857-89-7.
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
This Letter describes the further lead optimization of the VU0486321 series of mGlu1 positive allosteric modulators (PAMs), focused on addressing the recurrent issue of plasma instability of the phthalimide moiety. Here, we evaluated a number of phthalimide bioisosteres, and ultimately identified isoindolinones as the ideal replacement that effectively address plasma instability, while maintaining acceptable mGlu1 PAM potency, DMPK profile, CNS penetration and mGluR selectivity.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 35857-89-7
Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N925 – PubChem