Brief introduction of 3,6-Dichloropyridazine

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Synthesis of some novel 2,6-disubstituted pyridazin-3-ones as TMC120 analogues

(Chemical Equation Presented) Different analogues of TMC120 derived from pyridazin-3(2H)-one rings were synthesized by coupling of 3,6-dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N1802 – PubChem