New learning discoveries about N,N’-Diphenylthiourea

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Category: pyridazines.

Chemistry, like all the natural sciences, Category: pyridazines, begins with the direct observation of nature¡ª in this case, of matter.102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a document, author is Javed, Athar, introduce the new discover.

Synthesis, antimicrobial activity, and docking study of some N-3, N-6-diphenylpyridazine-3,6-diamine derivatives as dihydrofolate reductase inhibitors

Objective: The present study focussed on the synthesis of pyridazine analogs to explore broad-spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are studied later. Materials and Methods: All the synthesized compounds were characterized by spectroscopic techniques, namely, UV, IR,(HNMR)-H-1, and mass spectrometry. Antimicrobial activity was screened by serial dilution method and absorbance was recorded using ELISA reader, subsequently minimum inhibitory concentrations were determined. Docking study was done into the active site of dihydrofolate reductase using Auto Dock 4.2. Results: The present investigation about synthesis, characterization, and biological studies of some new pyridazine analogs were carried out to obtain potent and pharmacologically active compounds. The free energy of binding was in the range of 5.12 to 8.97 kcal/mole. In silico study report was in good tune with laboratory experiments. Conclusions: Most of the compounds were moderate-to-good toward the antimicrobial activity. Compound AJ27 was found to be most active. Results of anti-microbial activity establishes the importance of N-3, N-6-diphenylpyridazine-3,6-diamine as the basic skeleton required for the antimicrobial activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem