Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 50681-25-950681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Lucaioli, P., introduce new discover of the category.
The Impact of Trifluoroacetic Acid on Peptide Cocrystallization: Multicomponent Crystals of L-Leu-L-Leu Dipeptides
In a previous contribution, entitled First Steps for the Direct Purification of L-Leu-L-Leu Dipeptide through Cocrystallization, we reported and evidenced cocrystallization as a route to purify freshly synthesized trifluoroacetic acid (TFA)-contaminated Leu-Leu peptides. In this contribution ternary and quaternary crystal forms, isolated as transient phases to the previously reported pure cocrystals, are presented. This contribution and the one previously reported present the outcomes of large cocrystallization screening undertaken on the LLeu-L-Leu dipeptide, where a competing range of multiple crystal forms from target cocrystal to TFA salt is accessible. As a key point for this contribution we report the isolation of transient phases that consist of Leu-Leu peptide (both with amidic and carboxylic C-terminals) either with pyridazine, 1H-pyrazole, pyridine N-oxide, or pyrazine plus TFA, or solvent alcohol or water with TFA. Such a diversity of multicomponent phases add further to the understanding of the differential crystallization process established when cocrystallization is used to purify the crude synthesized peptide product contaminated with TFA. A description of the overall packing landscape was undertaken from a crystal engineering point of view to illustrate how the presence of trifluoroacetate anions, strong hydrogen bond acceptors, affect the crystal packing. Typically, the Leu-Leu peptide forms a multilayered structure with guest in cavities between the layers; however, alternative novel arrangements were also seen. The structures are part of a wide landscape of possible complexes that are difficult to isolate, as they often represent transient phases that are hard to reproduce. Nevertheless, the reported phases give further insight into the purification through cocrystallization pathway and, critically, help to understand the interplay between crystal growth and the packing landscape.
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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem