Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 110-03-2, Name is 2,5-Dimethyl-2,5-hexanediol, molecular formula is C8H18O2, belongs to pyridazines compound. In a document, author is Wang, Shuo, introduce the new discover, COA of Formula: C8H18O2.
A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift
Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play key roles in biological processes, and detecting such thiols selectively is critical for understanding functions of biothiols. In this work, a pyridazine annelated perylene-based fluorescent probe PAPC is synthesized for highly selective detection of Cys. PAPC exhibits strong blue emission in PBS, while the red emission at 605 nm can be observed in the presence of Cys. The probe PAPC shows ratiometric fluorescence (I-605/I-460) detection of Cys with wide linear range of 1-120 mu M and low detection limit of 0.19 mu M. Super large Stokes shift (170 nm) and ratiometric fluorescence endow the probe low background signal. The discrimination of Cys over Hcy and GSH can be achieved through the difference of the ratiometric fluorescence. In addition, the probe has been proven to track Cys in real samples such as urine and HeLa cells. Therefore, PAPC probe is a promising candidate for detecting Cys in practical application. Graphical abstract
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 110-03-2. COA of Formula: C8H18O2.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem