Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, SMILES is C3=C([P](C1=CC=CC=C1)(C2=CC=CC=C2)=CC(OC)=O)C=CC=C3, belongs to pyridazines compound. In a document, author is Elmeligie, Salwa, introduce the new discover, Category: pyridazines.
Design and Synthesis of Pyridazine Containing Compounds with Promising Anticancer Activity
Certain pyridazine containing compounds 2a-f, 3a, b, 4a, b, 5a, b, 6a and b were synthesized and characterized by spectroscopic means and elemental analysis. All the synthesized compounds were screened for their cytotoxic activity in vitro on colon cancer cell line (HCT-116) and breast cancer cell line (MCF-7). In addition, the antitumor activity of the synthesized compounds was tested in vivo against Ehrlich’s ascites carcinoma (EAC) solid tumor grown in mice. The in vitro vascular endothelial growth factor receptor (VEGFR) enzyme inhibition assay was carried out for the most active compounds at a single dose of 10 mu m. The obtained results revealed that compound 5b, which showed potent cytotoxic activity against HCT-116 also, exhibited the highest inhibition in the VEGFR kinase assay (92.2%).
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2605-67-6 is helpful to your research. Category: pyridazines.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem