The important role of 3,6-Dichloropyridazine

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 141-30-0, name is 3,6-Dichloropyridazine, introducing its new discovery. Application In Synthesis of 3,6-Dichloropyridazine

SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES

This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an alpha1 -GABA-A receptor antagonist and/or a alpha2, alpha3 and alpha5 GABA-A receptor agonist.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1334 – PubChem

 

More research is needed about 4,5-Dichloro-2-phenylpyridazin-3(2H)-one

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New enediyne derivatives: Synthesis of symmetrically and unsymmetrically disubstituted 4,5-dialkynyl-3(2H)-pyridazinones

4,5-Dialkynyl-2-(methyl or phenyl)-3(2H)-pyridazinones (2a-c) were efficiently prepared via Sonogashira cross-coupling reaction on 4,5-dichloro-2-(methyl or phenyl)-3(2H)-pyridazinones (1a,b). Selective Sonogashira reactions were successfully achieved on 4-chloro-2-methyl-5-trifluoromethanesulfonyloxy- (6) and 5-chloro-2-methyl-4-trifluoromethanesulfonyloxy-3(2H)-pyridazinone (11), yielding 5-alkynyl-4-chloro- (7a-c) and 4-alkynyl-5-chloro-2-methyl-3(2H)-pyridazinones (3a,c,e), respectively. Compounds 7a-c and 3a,c,e were subjected to a second Sonogashira reaction giving 4,5-dialkynyl-2-methyl-3(2H)-pyridazinones (8a-c) bearing two different acetylene substituents. Suzuki cross-coupling reaction was also achieved on compounds 7a and 3a producing 4-aryl-5-phenylethynyl- and 5-aryl-4-phenylethynyl-2-methyl-3(2H)-pyridazinones, respectively, in excellent yield.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3111 – PubChem

 

Some scientific research about 41933-33-9

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Synthetic Route of 41933-33-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 41933-33-9, Name is 2-Benzyl-4,5-dichloropyridazin-3(2H)-one,introducing its new discovery.

An efficient and practical method for the synthesis of 1-(2,6- difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as potential chitin synthesis inhibitors

A mild and efficient method for the synthesis of 4-amino-3(2H)- pyridazinones from their corresponding 4,5-dichloropyridazinones under microwave-assisted conditions is described. A series of novel chitin synthesis inhibitors, benzoylphenylureas containing the 3(2H)-pyridazinone, were synthesized. The biological activity of these target compounds was evaluated. Springer-Verlag 2006.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3201 – PubChem

 

Awesome Chemistry Experiments For Methyl pyridazine-3-carboxylate

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Pyridazines. LII. Novel 1,2-Diazine Analogues of 2-Aminobenzophenone via Directed Lithiation

The preparation of novel pyridazine analogues of 2-aminobenzophenone, namely 2-(substituted)aminophenyl 3-pyridazinyl ketones 2, 3, 4a,b, achieved by reaction of methyl 3-pyridazinecarboxylate with ortho-lithiated aniline derivatives, is reported.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N800 – PubChem

 

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Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent£¬once mentioned of 141-30-0

SUBSTITUTED PIPERIDINYL-PYRIDAZINYL DERIVATIVES USEFUL AS SCD 1 INHIBITORS

The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1568 – PubChem

 

Some scientific research about 4-Chloro-5-methoxypyridazin-3(2H)-one

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Direct functionalization of 4,5-dichloropyridazin-6-one

Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo- 4-substituted-pyridazin-6-ones as main product. Reaction of 4,5- dichloropyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)pyridazin-6-one as the main product.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2187 – PubChem

 

Extended knowledge of 3,6-Dichloropyridazine

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Electric Literature of 141-30-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 141-30-0, molcular formula is C4H2Cl2N2, introducing its new discovery.

Non-nucleoside reverse transcriptase inhibitors

This invention relates to novel pyridazinone derivatives of formula I wherein R1-R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I. The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated 1

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1361 – PubChem

 

Some scientific research about 3-Bromo-6-chloropyridazine

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HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer’s Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson’s disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2832 – PubChem

 

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Reference of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

Photoredox-Catalysed Decarboxylative Alkylation of N-Heteroarenes with N-(Acyloxy)phthalimides

An iridium photoredox catalyst in combination with either a stoichiometric amount of Br¡ãnsted acid or a catalytic amount of Lewis acid is capable of catalyzing regioselective alkylation of N-heteroarenes with N-(acyloxy)phthalimides at room temperature under irradiation. A broad range of N-heteroarenes can be alkylated using a variety of secondary, tertiary, and quaternary carboxylates. Mechanistic studies suggest that an IrII/IrIIIredox catalytic cycle is responsible for the observed reactivity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1647 – PubChem