Final Thoughts on Chemistry for 64068-00-4

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Facile synthesis of 4-aryl and alkyl substituted, N6-alkylated pyridazine-3,6-diamines

Substituted pyridazine-3,6-diamines are attractive but poorly precedented scaffolds in medicinal chemistry and are challenging targets in terms of synthetic tractability. In the following communication we report the use of a Buchwald protocol for the facile synthesis of 4-aryl and alkyl substituted, N6-alkylated pyridazine-3,6-diamines. This approach utilises the unreactive nature of the pyridazine 3-amino group, negating the need for an additional protecting group in the transformation. The relevant precursors were prepared by selective Suzuki or Negishi transformations using commercially available 4-bromo-6-chloro-3-pyridazinamine.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1065 – PubChem

 

Extracurricular laboratory:new discovery of 6-Methylpyridazin-3-amine

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AN NMR INVESTIGATION OF THE GEOMETRICAL ISOMERISM IN THE ANIONS AMINO COMPOUNDS

The nmr spectra of the anions of 2-, 6- and 8-aminopurines, 2- and 4-aminopyrimidines, 3- and 4-aminopyridazines, aminopyrazine, 2-aminopyridine, aniline and its p-methyl derivative in liquid ammonia containing potassium amide at low temperature show the presence of two geometrical isomers, due to restricted rotation of the deprotonated amino group.The occurrence of coalescence has been observed with aminopyrazine and p-methylaniline.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N238 – PubChem

 

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GLYCOSIDE DERIVATIVES AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment

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Pyridazine – Wikipedia,
Pyridazine | C4H4N831 – PubChem

 

Brief introduction of 3-Chloro-6-methylpyridazine

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3-(3-PYRIMIDIN-2-YLBENZYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS

Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

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Pyridazine | C4H4N567 – PubChem

 

The Absolute Best Science Experiment for 5-Chloropyridazine-3-carboxylic acid

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1211587-01-7, name is 5-Chloropyridazine-3-carboxylic acid, introducing its new discovery. Product Details of 1211587-01-7

Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2037 – PubChem

 

Extracurricular laboratory:new discovery of 1698-53-9

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PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS

The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3079 – PubChem

 

Properties and Exciting Facts About 3-Phenyl-6-chloropyridazine

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Reagent-controlled diastereoselective synthesis of (2S,3R)- and (2R,3R)-2,3-diaminobutanoic acid derivatives using proline-catalyzed alpha-hydrazination reaction

(2S,3R)- and (2R,3R)-2,3-Diaminobutanoic acid (Dab) derivatives were efficiently synthesized from Cbz-(R)-alanine using the proline-catalyzed diastereoselective alpha-hydrazination reaction and the SmI2-promoted reductive cleavage of the N-N bond as the key steps.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2692 – PubChem

 

Extended knowledge of 6-Chloropyridazine-3-carbonitrile

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TRICYCLIC INDOLE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS

The present invention is directed to tricyclic indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.

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Pyridazine – Wikipedia,
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More research is needed about 4-Chloro-5-methoxypyridazin-3(2H)-one

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Retro-ene reaction, VI. Functionalization of 4,5-dihalopyridazin-6-ones using 1-acetyloxymethyl-4,5-dihalopyridazin-6-ones as the 1-o, 3-n, 5-o ene- adduct

Functionalization of 1-acetyloxymethyl-4,5-dihalopyridazin-6-ones via retro-ene reaction with some nucleophiles gave regioselectively only 5-halo- 4-substitutedpyridazin-6-ones.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2186 – PubChem

 

Some scientific research about 141-30-0

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TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS

The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1344 – PubChem