Month: March 2021

Chemistry is traditionally divided into organic and inorganic chemistry. name: 3-Phenyl-6-chloropyridazine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 20375-65-9

Synthesis of steroidal triply-bridged cyclophanes

Steroidal triply-bridged cyclophanes are synthesised using cholic acid derivatives as bridge units; cyclophane 3 moderately binds to organic guest molecules and enantio-selectively binds to N-Z-phenylalanine.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2678 – PubChem

 

Related Products of 5788-58-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 5788-58-9, Name is 4,5-Dibromopyridazin-3(2H)-one,introducing its new discovery.

MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS

The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3167 – PubChem

 

Synthetic Route of 141-30-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Article£¬once mentioned of 141-30-0

Selective deoxygenation of heteroaromatic N-oxides with olefins catalyzed by ruthenium porphyrin

A new convenient method of deoxygenation of heteroaromatic N-oxides is described. Ruthenium porphyrin was used as a catalyst and this method expressed high yields for o-substituted pyridine N-oxides, quinoline N-oxide derivatives, acridine N-oxide, etc. under mild conditions. Moreover, nitro-, benzyloxy-, and ketone carbonyl groups, which can be affected by the usual deoxygenation methods such as catalytic hydrogenation or borane reduction, were retained.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1834 – PubChem

 

Electric Literature of 1837-55-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1837-55-4, Name is 3,5-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a Patent£¬once mentioned of 1837-55-4

COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1181 – PubChem

 

Related Products of 141-30-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 141-30-0, Name is 3,6-Dichloropyridazine,introducing its new discovery.

CD73 INHIBITORS

The present invention provides 5-[5]-[2-cycloa Ikyl ]-6-pyridazin-3-yl ]- IH-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer. (Formula (I))

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1275 – PubChem

 

Electric Literature of 91063-19-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 91063-19-3, Name is 3-(Benzyloxy)-6-chloropyridazine, molecular formula is C11H9ClN2O. In a Article£¬once mentioned of 91063-19-3

Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vitro antiproliferative activity of these products was evaluated against a representative panel of cancer cell lines (HuH7, CaCo-2, MDA-MB-231, HCT116, PC3, NCI-H727, HaCaT) and oncogenicity prevention of the more efficient derivatives was highlighted on human breast cancer cell line MDA-MB 468-Luc prior establishing their interaction with p44/42 and Akt-dependent signaling pathways.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2922 – PubChem

 

Related Products of 141-30-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 141-30-0, 3,6-Dichloropyridazine, introducing its new discovery.

Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands

Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent alpha7 NNR agonist activity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1788 – PubChem

 

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Formula: C4H2Cl2N2In an article, once mentioned the new application about 141-30-0.

Pyridazine-derived gamma-secretase modulators

SAR of a novel series of pyridazine-derived gamma-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Abeta42 and Abeta40, and maintain the levels of total Abeta. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1942 – PubChem

 

141-30-0, Name is 3,6-Dichloropyridazine, belongs to pyridazine compound, is a common compound. Recommanded Product: 3,6-DichloropyridazineIn an article, once mentioned the new application about 141-30-0.

ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Disclosed herein are 3-azabicyclo[3.1.0]hexan-6-amine compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1432 – PubChem

 

Electric Literature of 135034-10-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 135034-10-5, Name is 3-Chloro-6-iodopyridazine,introducing its new discovery.

Pd-catalyzed chemoselective cross-coupling reaction of triaryl- or triheteroarylbismuth compounds with 3,6-dihalopyridazines

The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. The cross-coupling reactions of 3,6-dihalopyridazines with triaryl- or triheteroarylbismuth compounds were performed under palladium catalysis. The reaction was highly chemoselective, affording functionalized aryl- or heteroarylpyridazinyl chlorides in moderate to good yields. Copyright

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3070 – PubChem