The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of 4-Pyridazinecarboxylic Acid, 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, in an article , author is Park, Yong Dae, once mentioned of 50681-25-9.
A Pyridazine-Based Fluorescent Probe Targeting A beta Plaques in Alzheimer’s Disease
Accumulation of beta-amyloid (A beta) plaques comprising A beta 40 and A beta 42 in the brain is the most significant factor in the pathogenesis of Alzheimer’s disease (AD). Thus, the detection of A beta plaques has increasingly attracted interest in the context of AD diagnosis. In the present study, a fluorescent pyridazine-based dye that can detect and image A beta plaques was designed and synthesized, and its optical properties in the presence of A beta aggregates were evaluated. An approximately 34-fold increase in emission intensity was exhibited by the fluorescent probe after binding with A beta aggregates, for which it showed high affinity (K-D=0.35 mu M). Moreover, the reasonable hydrophobic properties of the probe (log P=2.94) allow it to penetrate the blood brain barrier (BBB). In addition, the pyridazine-based probe was used in the histological costaining of transgenic mouse (APP/PS1) brain sections to validate the selective binding of the probe to A beta plaques.) The results suggest that the pyridazine-based compound has the potential to serve as a fluorescent probe for the diagnosis of AD.
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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem