Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 39825-33-7, Name is H-Ala-OiPr, molecular formula is C6H13NO2, belongs to pyridazines compound. In a document, author is Liu, Chunjian, introduce the new discover, Application In Synthesis of H-Ala-OiPr.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 64(2oxo-Nl -substituted-1,2-dihydropyridin-3-y1) amino)imi dazo[1,2-Npyridazine analogs were found to display dramatically improved metabolic stability. The N1-substituent on 2-oxo-1,2dihydropyridine ring can be a variety of alkyl, aryl, and heteroaryl groups, but among them, 2-pyridyl provided much enhanced Caco-2 permeability, attributed to its ability to form intramolecular hydrogen bonds. Further structure activity relationship studies at the C3 position led to the identification of highly potent and selective Tyk2 JH2 inhibitor 6, which proved to be highly effective in inhibiting IFNy production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 39825-33-7. Application In Synthesis of H-Ala-OiPr.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem