Let¡¯s face it, organic chemistry can seem difficult to learn, Safety of 3-Amino-6-chloropyridazine, Especially from a beginner¡¯s point of view. Like 5469-69-2, Name is 3-Amino-6-chloropyridazine, molecular formula is C10H11NO2, belongs to oxazolidines compound. In a document, author is Anikin, Oleg V., introducing its new discovery.
Intramolecular Reaction of tert-Butyl-NNO-Azoxy and Cyano Groups – Novel Synthesis of Pyridazine, 1,2,3-Triazepine, and Furan Rings
A reaction of (tert-butyl-NNO-azoxy)acetonitrile with N,N-dimethylacetamide dimethylacetal afforded 2,4-bis(tert-butyl-NNO-azoxy)-3-methylpent-2-enedinitrile 9 as a main product. This compound cyclized on silica gel surface with the loss of isobutylene to give 6-amino-5-(tert-butyl-NNO-azoxy)-4-methylpyridazine-3-carbonitrile 2-oxide 10. On the contrary, the cyclization of dinitrile 9 in protic solvents resulted in quite different products: furan, 1,2,3-triazepine, and pyridazine derivatives were among them. These reactions are the first examples of intramolecular reactions of (tert-butyl-NNO-azoxy) and cyano groups. The structures of products under investigation were confirmed by X-ray diffraction analysis.
If you are hungry for even more, make sure to check my other article about 5469-69-2, Safety of 3-Amino-6-chloropyridazine.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem