Chemistry, like all the natural sciences, Quality Control of H-Ala-OiPr, begins with the direct observation of nature¡ª in this case, of matter.39825-33-7, Name is H-Ala-OiPr, SMILES is C[C@H](N)C(OC(C)C)=O, belongs to pyridazines compound. In a document, author is Carmen Costas-Lago, Maria, introduce the new discover.
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors
Compounds of hybrid structure pyridazine-coumarin were discovered as potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B). These compounds were synthesized in good yield following a multistep approach based on Knoevenagel reaction and using as key intermediate pyridazinone 16, which was obtained from maleic anhydride and furan. Compounds 9b and 9d are the most active compounds of these series, with IC50 values in the sub-micromolar range, and lack of cytotoxic effects. Theoretical calculation of ADME properties also suggested a good pharmacokinetic profile for both compounds. Docking simulations provided insights into enzyme inhibitor interactions and allowed us to rationalize the observed structure-activity relationships (SARs). (C) 2017 Elsevier Masson SAS. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 39825-33-7. Quality Control of H-Ala-OiPr.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem