Electric Literature of 375-72-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 375-72-4, Name is 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride, SMILES is O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(F)=O, belongs to pyridazines compound. In a article, author is Komendantova, Anna S., introduce new discover of the category.
Cyclization of beta-Chlorovinyl Thiohydrazones into Pyridazines: A Mechanistic Study
Extensive experimental and theoretical investigations on the isomerization and heterocyclizations of -chlorovinyl thiohydrazones derived from oxamic acid thiohydrazides and -chlorovinyl aldehydes were performed to elucidate the reaction mechanism of pyridazine formation. We showed that model -chlorovinyl thiohydrazone undergoes multiple isomerization reactions in solution induced by thione-thiol tautomerism and Z/E-isomerization at the C=N bond. Mechanistic rationalization along with computational studies demonstrated that pyridazine is predominantly generated from the Z-thiol isomers by 6-electrocyclization of the thiohydrazone-derived 2,3-diazatriene intermediate. The autocatalytic character of cyclization accelerated by the formation of acid was demonstrated by means of H-1 NMR monitoring.
Electric Literature of 375-72-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 375-72-4 is helpful to your research.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem