Application of 110-03-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 110-03-2, Name is 2,5-Dimethyl-2,5-hexanediol, SMILES is CC(C)(O)CCC(C)(C)O, belongs to pyridazines compound. In a article, author is Duvall, Bridget, introduce new discover of the category.
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker
A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (-SCH2CH2-) linker were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a prototype allosteric inhibitor of GLS. BPTES analog 3a with a mercaptoethyl linker between the two thiadiazole rings was found to potently inhibit GLS with an IC50 value of 50 nM. Interestingly, the corresponding derivative with an n-propyl (-CH2CH2CH2-) linker showed substantially lower inhibitory potency (IC50 = 2.3 mu M) while the derivative with a dimethylsulfide (-CH2SCH2-) linker showed no inhibitory activity at concentrations up to 100 mu M, underscoring the critical role played by the mercaptoethyl linker in the high affinity binding to the allosteric site of GLS. Additional mercaptoethyl-linked compounds were synthesized and tested as GLS inhibitors to further explore SAR within this scaffold including derivatives possessing a pyridazine as a replacement for one of the two thiadiazole moiety.Y
Application of 110-03-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 110-03-2.
Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem