Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Othman, Ismail M. M., once mentioned the application of 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P, molecular weight is 334.35, MDL number is MFCD00008455, category is pyridazines. Now introduce a scientific discovery about this category, Computed Properties of C21H19O2P.
Synthesis, characterization, and biological studies of some novel pyrazole carboxamide, pyridazine and thienopyridazine derivatives
The arylhydrazones 3a, b were prepared and reacted with various reagents to yield the target compounds pyrazoles 6a-f, 1,6-dihydropyridazine-3-carboxamide derivatives 9a,b and thieno[3,4-d]pyridazine-1-carboxamide derivatives 10a,b. The structures of the synthesized compounds were confirmed by various spectral data and elemental analyses. Furthermore, all target derivatives were tested for their antibacterial bioactivity against different types of Gram+ve and Gram-ve strains and for antifungal activity against two fungi micro-organisms by well diffusion method. Thus, the observed results showed that the 5-cyano-6-imino-N-(4-methoxyphenyl)-4-methyl-1-phenyl-1,6-dihydropyridazine-3-carboxamide (9b) displayed the best antimicrobial activity (with MIC values ranged from 0.49 +/- 0.2 to 3.9 +/- 0.6 mu g/mL).
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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem